Reference of 611-09-6,Some common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, molecular formula is C8H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of acetophenone or isatin (5 mmol) in THF (10 mL), BF3¡¤OEt2 (7.5 mmol) was added at 0C under the atmosphere of N2 and the mixture was stirred for 10 minutes. To the cooled mixture, anhydrous hydrazine (7.5 mmol) was added in one portion and the reaction mixture was stirred at 0C under the atmosphere of N2 for 30 min. The reaction was quenched by the addition of a saturated solution of NH4Cl (4 mL), extracted by ethyl acetate (3 ¡Á 15 mL) and purified by column chromatography (ethyl acetate-CH2Cl2; 3 : 7) to afford hydrazones 2-22.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Nitroindoline-2,3-dione, its application will become more common.
Reference:
Article; El-Azab; Ghabbour; El-Husseiny; Maarouf; Mohamed; Abdel-Aziz; Russian Journal of General Chemistry; vol. 86; 12; (2016); p. 2837 – 2844; Zh. Obshch. Khim.; vol. 86; 12; (2016); p. 2837 – 2844,8;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem