Related Products of 6326-79-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6326-79-0, name is 6-Bromoisatin belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
As shown in Fig. 133B, a mixture of compound 1 (721 mg, 3.20 mmol, 1.0 eq), compound la (2092) (560 mg, 3.20 mmol, 1.0 eq) and sodium carbonate (866 mg, 8.17 mmol, 2.55 eq) in methanol (10 mL) was stirred at room temperature for 3 h under nitrogen atmosphere. The progress of the reaction mixture was monitored by TLC. After completion of the reaction, the mixture was filtered and the filter cake was washed with methanol and water to afford compound AB17653 (979 mg, 89%) as a red solid. TLC: PE/EA = 3/1, 254 nm; Rf (Compound 1) = 0.6; Rf (Compound AB17653) = 0.4; LC-MS: 338.95 (M-l) ; NMR (400 MHz, d6-DMSO) 511.01 (d, J = 21.5 Hz, 2H), 8.64 (d, J = 8.3 Hz, 1H), 7.62 (d, J = 7.7 Hz, 1H), 7.55 (t, J = 7.6 Hz, 1H), 7.39 (d, J = 8.1 Hz, 1H), 7.18 (d, J = 8.4 Hz, 1H), 7.00 (dd, J = 8.8, 4.6 Hz, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Bromoisatin, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; EINZIGER, Michael; SIMPSON, Ann, Marie; (499 pag.)WO2019/200232; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem