Synthetic Route of 2058-74-4, The chemical industry reduces the impact on the environment during synthesis 2058-74-4, name is 1-Methylisatin, I believe this compound will play a more active role in future production and life.
General procedure: The dicationic ionic liquid 10 (27.03 mg, 10 mol %), was added to a mixture of 1,3-dicarbonyl (1 mmol), isatin (1 mmol), malononitrile (1 mmol), and K2CO3 (13.8 mg, 10 mol %) in water (3 mL). The reaction mixture was stirred at reflux for the appropriate time. After reaction completion (TLC), the reaction mixture was cooled to room temperature and filtered. The filtrate was washed with cool ethanol (3 ¡Á 5 mL) to obtain the corresponding 4H-pyran. The crude products were purified by recrystallization from ethanol (95%). To recover 10, the ethanol/water phase was evaporated under reduced pressure and the crude was washed with ethyl acetate (3 ¡Á 5 mL) and air dried.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylisatin, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Niknam, Khodabakhsh; Khataminejad, Mohsen; Zeyaei, Fariba; Tetrahedron Letters; vol. 57; 3; (2016); p. 361 – 365;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem