Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 825-70-7, name is 5-Fluoro-2-methylindoline, A new synthetic method of this compound is introduced below., Formula: C9H10FN
5-Fluoro-2-methylindoline 16a (1.30 g, 8.60 mmol, prepared according to the known method disclosed in “”) and 3b (1.47 g, 8.60 mmol) were dissolved in 40 mL of dichloromethane successively, and stirred for 2 hours. The reaction solution was then added with sodium triacetoxyborohydride (2.73 g, 12.90 mmol), and reacted for 12 hours after addition. The reaction solution was poured into 50 ml of water, and the water phase was extracted with dichloromethane (50 mL*2). The organic phases were combined, dried over anhydrous sodium sulfate, and filtered.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.; LI, Xin; HE, Wei; WANG, Bin; ZHANG, Zhigao; HE, Feng; TAO, Weikang; (104 pag.)EP3560918; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem