Application of 550-44-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 550-44-7, name is 2-Methylisoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
1) Production of 1,1,2,3,3-pentamethylisoindoline: With cooling with ice, 1.40 g of zirconium chloride was added to 6.0 mL of a THF solution of 483 mg of N-methylphthalimide, and stirred for 30 minutes with cooling with ice. 18.7 mL of 0.96 M methylmagnesium chloride/THF solution was added to it, and stirred at room temperature for 18 hours. With cooling with ice, 20 mL of aqueous 5 M sodium hydroxide solution was added to the reaction liquid, and extracted with chloroform. The organic layer was dried with anhydrous sodium sulfate, and the solvent was evaporated away under reduced pressure. The crude product was purified through NH silica gel column chromatography (hexane/ethyl acetate) to obtain 105 mg of the entitled compound as a yellow solid. 1H-NMR (400 MHz, CDCl3) delta: 7.25-7.20 (2H, m), 7.17-7.13 (2H, m), 2.42 (3H, s), 1.33 (12H, s) ESI-MS Found: m/z [M+H]+ 190
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methylisoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Banyu Pharmaceutical Co., Ltd.; EP2168966; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem