Adding a certain compound to certain chemical reactions, such as: 3676-85-5, name is 5-Aminoisoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3676-85-5, Safety of 5-Aminoisoindoline-1,3-dione
6: A suspension of 4-amino-phthalimide 5 (6.48 g, 39.9 mmol) in hydrochloric acid (18%, 120 mL) was cooled to 0 C. A solution of sodium nitrite (3.25 g, 47.2 mmol) in H2O (8.0 mL) was added dropwise. The resulted yellow solution was stirred at 0 C for 1 h. A suspension of CuCl (5.90 g, 59.9 mmol) in H2O (8.0 mL) was added to the above solution slowly. The mixture was stirred at 0 C for 3 h and further stirred at 50 C for 1 h. The precipitate was collected by filtration washed by water, dried in vacuum affording a light yellow solid 6 (4.90 g, 68% yield). 1H NMR (DMSO-d6): delta (ppm) 11.50 (s, 1H, CONHCO), 7.88 (d, 1H, 1.6 Hz), 7.87-7.82 (m, 2H). 13C NMR (DMSO-d6): delta (ppm) 168.23, 167.83, 138.99, 134.57, 134.00, 131.12, 124.64, 122.95.
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Reference:
Article; Song, Xiaoyu; Zhao, Jing; Zhang, Wandong; Chen, Long; Chinese Chemical Letters; (2018); p. 331 – 335;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem