Synthetic Route of 4702-13-0,Some common heterocyclic compound, 4702-13-0, name is N-Phthaloylglycine, molecular formula is C10H7NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of amino-acid phthalyl derivative(0.001 mol) and thionylchloride (6 mL) was refluxed for 3 h at 50C. The excess of thionylchloride was vacuum distilled.Anhydrous toluene was added to the reaction flask and distilled off in vacuo three times for complete removal of thionylchloride.Then, obtained chlorides 2 and 3 were used for acylation.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Phthaloylglycine, its application will become more common.
Reference:
Article; Gabbasov; Tsyrlina; Spirikhin; Yunusov; Chemistry of Natural Compounds; vol. 54; 5; (2018); p. 951 – 955; Khim. Prir. Soedin.; 5; (2018); p. 806 – 809,4;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem