These common heterocyclic compound, 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 5-Bromo-1-methylindoline-2,3-dione
General procedure: A solution of isatin derivatives 1 (0.4 mmol), dienones 2 (0.6 mmol) and sarcosine (0.8 mmol) in CH3CN (10.0 mL) was stirred at 80 oC for 24 h. After completion of the reaction, as indicated by TLC, the reaction mixture was directly subjected to flash column chromatography on silica gel (petroleum ether/EtOAc = 5:1~3:1) to furnish the corresponding products 3.
The synthetic route of 5-Bromo-1-methylindoline-2,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Xiong-Li; Yang, Chao; Zhang, Wen-Hui; Zhou, Gen; Ma, Xi-Tao; Lin, Bing; Zhang, Min; Zhou, Ying; Feng, Ting-Ting; Tetrahedron Letters; vol. 57; 12; (2016); p. 1385 – 1389;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem