Application of 774-47-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 774-47-0 name is 5,6-Difluoroindoline-2,3-dione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a stirred solution of potassium hydroxide (5 equiv.) in water (4 mL/g) in an ice-water bathwas added the isatin (1 equiv.) portionwise. The reaction mixture was stirred at roomtemperature for 10 minutes, then cooled in an ice-water bath and acetone (4 mL/g) wasadded dropwise. The reaction mixture was stirred in a 70 C heating block for the specifiedtime, then was cooled in an ice-water bath and a solution of aqueous 5 M hydrochloric acidwas added dropwise until the mixture reached pH 5-6. The reaction mixture was stirred atroom temperature for 10 minutes and then filtered. The resultant solid was filtered, driedand purified as specified
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5,6-Difluoroindoline-2,3-dione, and friends who are interested can also refer to it.
Reference:
Article; Lindsay-Scott, Peter J.; Barlow, Helen; Synlett; vol. 27; 10; (2016); p. 1516 – 1520;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem