Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 552330-86-6, name is 5-Bromoisoindolin-1-one, This compound has unique chemical properties. The synthetic route is as follows., name: 5-Bromoisoindolin-1-one
Step 1: 5-(Benzylthio)isoindolin-1-one (0478) (0479) Benzyl mercaptan (11.71 g, 94.32 mmol) was added to 5-bromoisoindolin-1-one (10 g, 47.16 mmol) and sodium 2-methyl-2-butoxide (5.19 g, 47.16 mmol) in DMF (100 mL) under nitrogen. The resulting mixture was stirred at 100 C. for 2 hours. The reaction mixture was quenched with water (300 mL) and extracted with EtOAc (3¡Á300 mL). The organic layer was dried over Na2SO4, filtered and evaporated to dryness to afford 5-(benzylthio)isoindolin-1-one (7.00 g, 58.1%) as a yellow solid. (0480) LC/MS: m/z=256 [M+H]+. 1H NMR (300 MHz, DMSO-d6) delta 4.33 (s, 2H), 4.35 (s, 2H), 7.23-7.61 (m, 8H), 8.48 (s, 1H).
According to the analysis of related databases, 552330-86-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AstraZeneca AB; NARJES, Frank; OLSSON, Roine Ingemar; VON BERG, Stefan; LEVER, Sarah; (112 pag.)US2017/166527; (2017); A1;,
Indoline – Wikipedia,
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