Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59-48-3, name is Indolin-2-one, This compound has unique chemical properties. The synthetic route is as follows., name: Indolin-2-one
Step 1: Spiro[cyclopropane-1, 3? -indoline] -2?-one An oven dried round bottom flask equipped with dropping funnel capped with rubber septum and nitrogen inlet and set in a removable dry ice-acetone bath was purged with nitrogen, and charged with an indolin-2-one (30.0 g, 225.3 mrnol), diisopropylamine (66.3 mL, 470.3 mmol) and dry THF (400 mL)The content of flask was cooled to -20C. The starting material was partially dissolved in THF at room temperature, re-precipitated as reaction mixture, and cooled down. A solution of n-BuLi as a 2.5 M solution in hexanes (360.5 mL, 901.2 mmol) was slowly transferred to dropping funnel viacannula, and then slowly added to the reaction mixture. The rate of addition was adjusted to keep the temperature of reaction mixture at -20 to -30C. When the addition was complete7 the dry ice bath was removed and replaced with regular ice bath, and the temperature was maintained at 0C for1 h. To the resulting reaction mixture was carefully added a solution of l,2-dibromoethane (58.24 mL, 675.9 mmol) in THE? (60 niL) . The resulting reaction mixture was then stirred 18 h at RT. The reaction mixture was then quenched with brine (40 mL), con.HC1 (60 mL) and water (180 mL). The resulted mixture(pH 2-3) upon standing separated into two layers. The Organic layer was removed, and the aqueous layer was extracted with ethyl acetate (200 niL) . The combined organic layer was then washed successively with sat. aq. sodium bicarbonate solution, water and brine, dried over sodium sulfate and evaporated under reduced pressure to obtain a solid. The solid thus obtained was washed with heptane:water (1:1) to give the title compound as a solid (35 g, 97.6%)MS(ESI)m/z: 160.1 [M+l]; ?HNMR (400 MHz, DMSO-d6) : 5 1.50-1.55(m, 2H) , 1.44-1.48 (m, 2H) , 6.88-6.97 (m, 3H) , 7.14 (t, J =8.4 Hz, 1H), 10.6 (s, 1M).[0229]
According to the analysis of related databases, 59-48-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; DESHPANDE, Anil M.; BARAWKAR, Dinesh; PATIL, Santosh; BANKAR, Digambar; (178 pag.)WO2016/88903; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem