Adding a certain compound to certain chemical reactions, such as: 6341-92-0, name is 6-Chloroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6341-92-0, Product Details of 6341-92-0
117.6 mg (0.65 mmol) 6-chloroisatin, 174.8 mg (0.78 mmol) 1,3-diphenyl-1,3-propanedione, 50 mL THF and 5 mL DMF as solvent, 1 mL H2O2, and 14.7 mg AlCl3 as catalyst were added to a 100 mL round flask. The mixture was stirred and heated at 70 C. for 12 hours. The reaction was monitored with TLC. When TLC indicated that reaction was complete, heating was removed. The reaction mixture was concentrated, filtered, and purified by fresh chromatograph to obtain 64.1 mg desired product (compound 11), a yield of 21.5%. 1H-NMR (300 MHz, DMSO-d6) delta (ppm): 10.76 (1H, s), 7.65?7.89 (5H, m), 7.23?7.82 (5H, m), 7.25 (1H, d), 6.95 (1H, s), 6.81 (1H, d); 13C-NMR (75 MHz, DMSO-d6) delta (ppm): 174.8, 169.5, 152.3, 137.9, 136.8, 134.5, 131.3, 129.2, 128.8, 128.5, 128.2, 127.8, 125.2, 121.3, 119.5, 111.9, 100.7, 92.5; MS (ESI) for (M+H)+: 388.1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Chloroisatin, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY; Liang, Chengyuan; Tian, Danni; Jia, Minyi; (11 pag.)US10035808; (2018); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem