Electric Literature of 18711-13-2,Some common heterocyclic compound, 18711-13-2, name is 4,7-Dichloroindoline-2,3-dione, molecular formula is C8H3Cl2NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1- Synthesis of 4,7 dichloroisatin analogs [0143] An appropriate acetophenone and 4, 7-dichloroisatin were condensed in the presence of a catalytic amount of diethylamine to prepare the desired compound in quantitative yield. Example compounds: R1 = 4′-CN (PT-1-11); 2′-OCH3 (PT-1-12) ; 3*-OCH3 (PT-1-18) ; 2′,4′-OCH3 (PT-1-19); 2′,3*-OCH3 (PT-1-20); 3*,4OCH3 (PT-1-21); 3*,5*OCH3 (PT-1-22); 2′,3*,4′,-OCH3 (PT-1-23); 3*,4′,5*-OCH3 (PT-1-13); 4′-OC2H5 (PT-1-14); 4′-CF3 (PT-1-15); 4′- OCF3 (PT-1-16); 4′-N(CH3)2 (PT-1-17); 4′-OPh (PT-1-60); 4′-SCH3 (PT-1-67); and 4′-C(CH3)2 (PT-1-67).
The synthetic route of 18711-13-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GEORGETOWN UNIVERSITY; TORETSKY, Jeffrey, A.; BROWN, Milton, Lang; TOSSO, Perrer, N.; UREN, Aykut; KONG, Yali; WO2013/155341; (2013); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem