Electric Literature of 141452-01-9, A common heterocyclic compound, 141452-01-9, name is Methyl indoline-5-carboxylate, molecular formula is C10H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a 100-mL, one-necked, round-bottomed flask,sequentially charged with compound A (2.25 mmol, 1 equiv.), CS2 (11.25 mmol, 5 equiv.), K3PO4 (2.25 mmol, 1 equiv.) and 30 mL ofacetone. The mixture was stirred for 0.5 h at r.t. and then 4-(bromomethyl)benzoic acid (2.25 mmol, 1 equiv.) was added. TLCanalysis was used to indicate the completed reaction. The reactionmixture was concentrated to provide crude compound B.
The synthetic route of 141452-01-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xie, Rui; Li, Yan; Tang, Pingwah; Yuan, Qipeng; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 320 – 333;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem