Adding a certain compound to certain chemical reactions, such as: 954-81-4, name is N-(5-Bromopentyl)phthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 954-81-4, Recommanded Product: N-(5-Bromopentyl)phthalimide
Under a protective nitrogen atmosphere, sodium hydride (NaH, 48 mg, 1.2 mmol) is added into a solution of berbamine dihydrochloride (205 mg, 0.3 mmol) in N,N-dimethyl formamide (5 ml) at 0 C., after being stirred for 1 hour, 2-(5-bromoamyl)-isoindoline-1,3-dione (133 mg, 0.45 mmol) is added therein. The reaction solution is heated to 80 C. overnight. Then the reaction mixture is evaporated under vacuum, and purified by a preparative thin layer chromatography to give white or pale yellow compound (BS-BE-002) (98.4 mg, 39.8%). [0109] LC/MS m/z: M+1 824.2 100% (purity). 1H NMR (CDCl3) delta:7.8267.809 (dd, 2H, J=5.5 Hz, 5.5 Hz), 7.6927.680 (dd, 2H, J=6.0 Hz, 5.5 Hz), 7.267.243 (m, 2H), 7.0847.071 (d, 1H, J=6.5 Hz), 6.796.733 (m, 2H), 6.6236.607 (d, 1H, J=8.0 Hz), 6.529 (s, 1H), 6.395 (s, 1H), 6.272 (s, 1H), 5.971 (s, 1H), 4.0694.042 (t, 2H, J=6.5 Hz, 7.0 Hz), 3.783 (s, 2H), 3.750 (s, 3H), 3.7183.689 (t, 2H, J=7.0 Hz, 7.5 Hz), 3.610 (s, 1H), 3.399 (s, 1H), 3.2453.208 (m, 2H), 3.121 (s, 3H), 3.0232.779 (m, 6H), 2.569 (s, 3 H), 2.540 (s, 1H), 2.3702.338 (m, 1H), 2.250 (s, 3H), 1.9261.869 (m, 2H), 1.7884.682 (m, 3H), 1.5701.507 (m, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-(5-Bromopentyl)phthalimide, and friends who are interested can also refer to it.
Reference:
Patent; HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.; Xu, Rongzhen; Rong, Frank; Xie, Fuwen; Lai, Hongxi; US2013/158068; (2013); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem