These common heterocyclic compound, 3783-77-5, name is 2-(3-Oxobutyl)isoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-(3-Oxobutyl)isoindoline-1,3-dione
Prepare a cold (0C) solution OF 2- (3-OXOBUTYL) ISOINDOLE-1, 3-dione (6. 8 g, 31.5 mmol) in methanol (50 mL). Add Br2 (3.2 mL, 63 MMOL). Allow the reaction to warm to room temperature and stir for 15 hours. Add 10 M sulfuric acid (26 mL) and stir the mixture for 15 hours. Filter off the solids and dry in vacuo to afford 2- (4-BROMO-3- oxobutyl) ISOINDOLE-1, 3-dione (2.3 g). 1H NMR (CDCl3) 8 7.85-7. 90 (m, 2H), 7. 69-7.77 (m, 2H), 4.05 (t, J= 7 Hz, 2H), 3.96 (s, 2H), 3.15 (t, J= 7 Hz, 2H).
The synthetic route of 2-(3-Oxobutyl)isoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/9941; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem