In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17564-64-6 as follows. Application In Synthesis of 2-(Chloromethyl)isoindoline-1,3-dione
A solution of ammonium O,O-(2-methylpentane-2,4-diyl) dithiophosphate (1) (0.01 mol) was dissolved in absolute methanol (20 mL) and treated with N-(chloromethyl)phthalimide (0.01 mol). The mixture was reuxed for 1 h, fltered and concentrated by distillation under reduced pressure.The resulting concentrated solution crystallized at room temperature. The white solid was fltered, washed with diethylether and dried over P2O5. It was recrystallized with aMeOH:CHCl3 (9:1) mixture. Color: white; yield: 75-80%,m.p. 66C. Anal. found C 48.98; H 4.82; N 3.93; S 17.51%.Calcd. for C15H18NO4PS2 (371.42): C 48.51; H 4.88; N 3.77; S17.27%; IR, flm nu(cm-1): = 1719 (C=O); 526 (P-S); 719 (P=S);1120 [(P)-O-C]; 967 [P-O-(C)]; 1H NMR: delta = 7.96 (m, 4H,Har); 4.99 (s, 2H, OCH2), 2.51 (s, 1H, OCH), 1.95 (s, 1H, CH),1.5 (m, 3H, CH3), 1.20 (m, 2H, CH2), 1.14 (m, 3H, CH3); 13CNMR: delta = 167.4 (C=O); 135.0 (C2); 131.5 (C3), 123.5 (C4); 86.9(N-CH2); 60.1 (OCH2); 72.6 (OCH); 128.3 (CH); 27.0 (CH3);31.5 (CH2); 21.6 (CH3), 31P NMR: delta = 82.9.
According to the analysis of related databases, 17564-64-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Rastogi, Rupali; Gupta, Srasti; Tarannum, Nazia; Agarwal, Ranu; Butcher; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 192; 3; (2017); p. 300 – 306;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem