Some common heterocyclic compound, 32372-82-0, name is Isoindoline hydrochloride, molecular formula is C8H10ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 32372-82-0
a. 2-chloro-4-(2,3-dihydro-1H-isoindol-2-yl)-pyrimidine A mixture of 0.5 g (3.35 mmol) of 2,4-dichloro-pyrimidine, 0.5 g (3.2 mmol) of 2,3-dihydro-1H-isoindol-hydrochloride and 0.6 ml (3.4 mmol) of N-ethyl-diisopropylamine is stirred in 40 ml dichloromethane for 3 hours. Then the mixture is concentrated by evaporation, the residue is distributed in ethyl acetate/water, the organic phase is separated off and concentrated by evaporation. Yield: 0.4 g (55% of theory), Rf value: 0.4 (silica gel; dichloromethane/ethanol=19:1)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 32372-82-0, its application will become more common.
Reference:
Patent; Boehringer Ingelheim Pharma KG; US2003/55263; (2003); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem