In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61-70-1 as follows. SDS of cas: 61-70-1
Example Xl; 1 -methyl-5-nitro-1 ,3-dihvdro-indol-2-one2 g 1 -methyl-1 ,3-dihydro-indol-2-one are dissolved in 10 ml concentrated sulphuric acid and cooled to 00C . To this is added dropwise a solution of 620 mul concentrated nitric acid in 2 ml concentrated sulphuric acid and the mixture is stirred for 30 minutes. Then it is poured onto 50 g ice, stirred for 1 hour, the solid is removed by suction filtering and dried in vacuo. Yield: 1.7 g (65 % of theory) Mass spectrum (ESI+): m/z = 193 [M+H]+
According to the analysis of related databases, 61-70-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/16119; (2009); A1;,
Indoline – Wikipedia,
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