Adding a certain compound to certain chemical reactions, such as: 552330-86-6, name is 5-Bromoisoindolin-1-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 552330-86-6, Quality Control of 5-Bromoisoindolin-1-one
Step 3 5-(4,4,5 ,5-Tetramethyl-[ 1 ,3 ,2]diotaoxaborolan 2-yl) 2,3-diotahydro-iotasoiotandol-l-one[00356] 5-Bromo-2,3-dihydro-isoindol-l-one (230mg, 1 08mmol), bis(pmacolato)diboron(300mg, 1 18mmol), PdCl2dppf (25mg, 31 mol) and KOAc (320mg, 3 26mmol) are suspended in dioxane (4mL), purged with nitrogen for 5 minutes and then heated at 850C overnight The solvent is removed in vacuo and the residue partitioned between ethyl acetate and water The aqueous layer is extracted with ethyl acetate (3x) and the combined organic phases are washed once with brine, filtered through MgStheta4 and evaporated The solid residue is triturated with hexane and dried in vacuo to yield the title compound (185mg, 66 %) as a grey solid 1H-NMR (400MHz, CDCl3) delta ( pp)pl 37 (12H, s), 4 45 (2H, s), 6 38 (IH, br s), 7 87 (IH, d), 7 93 (2H, m)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromoisoindolin-1-one, and friends who are interested can also refer to it.
Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem