Related Products of 957204-30-7, A common heterocyclic compound, 957204-30-7, name is tert-Butyl 6-hydroxyindoline-1-carboxylate, molecular formula is C13H17NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-(tert-Butoxycarbonyl)-6-hydroxyindoline (400 mg), 2-bromo-4′-phenylacetophenone (515 mg), potassium carbonate (470 mg), and DMF (10 mL) were mixed, and the mixture was stirred at 70C for 12 hours. The reaction mixture was diluted with ethyl acetate (200 mL), and the organic layer was washed with saturated brine. The washed layer was dried over sodium sulfate anhydrate, and solvent was removed by evaporation. The residue was purified by silica gel flash column chromatography (Yamazen Hi-Flash L), to thereby yield the title compound (487 mg). NMR (CDCl3) delta: 1.54(9H,s),3.01(2H,t,J=8.7Hz),3.98(2H,t,J=8.7Hz),5.27(2H,s),6 .56(2H,br s),7.02(1H,d,J=8.3Hz), 7.38-7.43(1H,m), 7.45-7.51(2H,m),7.61-7.65(2H,m), 7.71(2H,d,J=8.5Hz), 8.08(2H,d,J=8.3Hz). MS (ESI) m/z :430 (M+H)+.
The synthetic route of 957204-30-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Daiichi Sankyo Company, Limited; EP2017263; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem