Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17702-83-9, name is 2-(8-Bromooctyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., name: 2-(8-Bromooctyl)isoindoline-1,3-dione
A solution of an alkylbromide of general formula (VIII) (1 eq) in dry DMF (0.5 mL/mmol) was added to a flask suited for microwave heating. The amine (VII) (1 eq) was dissolved in DMF and added to the reaction flask and then K2CO3 (3 eq) was added. The reaction mixture was heated in a microwave oven at 7O0C for 3 h. The reaction was quenched with water, extracted with EtOAc and the organic phase concentrated to dryness, purified by chromatography using appropriate mixture of MeOH/CHCI3/NH3 to afford protected amines of general formula (IX).; Preparation 6: 2-(8-(cvclohexyl(3-morpholinopropyl)amino)octyl)isoindoline-l,3-dione (compound 6). General procedure 3. Starting materials: compounds 1 and 3. 1H-NMR (DMSOd6): delta 7.89-7.82 (m, 4H), 3.58-3.52 (m, 6H), 2.39-2.21 (m, HH), 1.71-1.08 (m, 24H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Topotarget A/S; CHRISTENSEN, Mette Knak; BJOeRKLING, Fredrik; WO2010/142735; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem