Application of 65826-95-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 65826-95-1, name is 5-Methylindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Preparation 7; 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-1H-indol-6-ylamineThe synthetic procedure used in this preparation is outlined in Scheme G. Step 1 5-Methyl-6-nitroindolineTo a solution of 2.5 g 5-methylindoline in 20 ml. of concentrated. Sulfuric acid at 0 C. was added in portions 1.7 g of potassium nitrate, keeping the temperature below 5 C. After the addition was complete, the mixture was stirred at 5 C. for ten minutes and then poured onto ice. The aqueous solution was made alkykline with 10% sodium hydroxide and extracted with ethyl acetate. The organic layer was washed with brine and then dried over sodium sulfate, filtered and concentrated in vacuo. The residue crystallized on standing to give 2.75 g of 5-methyl-6-nitroindoline as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methylindoline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Berger, Jacob; Caroon, Joan Marie; Krauss, Nancy Elisabeth; Walker, Keith Adrian Murray; Zhao, Shu-Hai; Lopez-Tapia, Francisco Javier; US2010/160373; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem