Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, A new synthetic method of this compound is introduced below., SDS of cas: 102359-00-2
To a solution of compound 1 (177 mg, 05 mmol) in Py (5 mL) was added EDCI (382 mg, 1 mmol) followed by amine tert-butyl 2-amino-4-(thiophen-2-yl)phenylcarbamate (260 mg, 0.9 eq). The mixture was stirred at rt overnight. The reaction was concentrated to get a residue, which was extracted with EA/water to get compound 2 (218 mg, 62%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; REGENACY PHARMACEUTICALS, LLC; VAN DUZER, John, H.; MAZITSCHEK, Ralph; BLUM, Charles; (70 pag.)WO2020/68950; (2020); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem