These common heterocyclic compound, 19155-24-9, name is 3,3-Dimethylindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H11NO
Example 60; Preparation of Intermediate Compound 6OA; To a solution of compound 47C (0.30 g, 0.61 mmol) was added compound 5OA ( 98 mg, 0.61 mmol), CuI (58 mg, 0.31 mmol), K3PO4 (263 mg, 1.24 mmol), and 1 ,2-trans-diamino cyclohexane (73 muL, 0.61 mmol). The mixture was diluted with dioxane (4 mL) and degassed under house vacuum and filled with N2 six times. The reaction mixture was heated to 100 ¡ãC, stirred for 12 hours, cooled to rt, and concentrated under reduced pressure. The crude product was taken up in a 20:1 mixture of CH2CI2/MeOH (5 mL), filtered and concentrated under reduced pressure. The residue from the filtrate was purified using preparative thin-layer chromatography using a 3:1 mixture of hexanes/EtOAc as eluent to provide 125 mg EPO
The synthetic route of 3,3-Dimethylindolin-2-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCHERING CORPORATION; WO2008/54749; (2008); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem