2913-97-5, name is N-(2-Oxoethyl)phthalimide, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2913-97-5
Compound 2: NaBH(OAc)3 (3,05 g ;14,4 mmol) was added to a solution of N- ethylaniline (1,16 g ; 9,6 mmol) and 2-phthalimidoacetaldehyde (1) (2,72 g, 14,4 mmol) in CH2C12 (28 mL). After 24 h at 20¡ãC, CH2C12 was added and the organic phase was washed with H20, dried (MgS04) and evaporated. The crude product was purified by chromatography over silica gel (80:20 CH2Cl2-cyclohexane) to afford 2 as a yellow solid (2,71 g, 96 percent). 1H NMR (250 MHz, CDC13): delta 7,85 (m, 2H), 7,71 (m, 2H), 7.24 (t, J = 7,8 Hz, 2H), 6,86 (d, J = 7,8 Hz, 2H), 6.67 (t, J = 7,8 Hz, 1H), 3.91 (dd, J = 6,5, 8,1 Hz, 2H), 3,58 (dd, J = 6,5, 8,1 Hz, 2H), 3,46 (q, J = 6,9 Hz, 2H), 1.22 (t, J = 7,0 Hz, 3H). 13C NMR (63 MHz, CDC13): <5 168,0 (C), 147,2 (C), 133,7 (CH), 131 ,8 (C), 129,2 (CH), 123,0 (CH), 116,0 (CH), 111,9 (CH), 47,8 (CH2), 44,6 (CH2), 35,0 (CH2), 12,2 (CH3). MS: m/z = 295 (MH+). Anal, calcd for Ci8Hi8N202 (294,14), C 73.45, H 6,16, N 9,52. Found C 73,33, H 6,17, N 9,62.
The synthetic route of 2913-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITE PARIS DESCARTES; SLAMA-SCHWOK, Anny; BOUCHER, Jean-Luc; XU-LI, Yun; DEPREZ, Eric; HENRY, Etienne; DESSY, Chantal; FERON, Olivier; TARUS, Bogdan; WO2012/175516; (2012); A1;,
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