Electric Literature of 3339-73-9, These common heterocyclic compound, 3339-73-9, name is 3-(1,3-Dioxoisoindolin-2-yl)propanoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: PhB(OH)2 (6 mg, 0.05 mmol), and xylene (10 mL) were added to a round-bottom flask (100 mL), 1a (90 mg, 0.5 mmol), 2a (97 mg,0.5 mmol). A pressure equalising dropping funnel, in which 4 A molecular sieves (6 g) were placed, was installed onto the flask. Then a condenser was connected to the dropping funnel. After refluxing under stirring for 10 h, the reaction mixture was cooled down to room temperature, and evaporated to remove solvent. The resulting residuewas dissolved in EtOAc (20 mL), and then sequentially washed with 0.1 M NaOH (20 mL), water (20 mL), and brine (20 mL). The organic layer was dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure. The resulting residue was subjected to preparative TLC (eluted with PE/acetone (2/1, v/v), Rf = 0.43) to afford ethyl 2-(N-phenyl-2-(N-phenylacetamido)acetamido)acetate 3a (128 mg 72%) as a pale yellow oil.
Statistics shows that 3-(1,3-Dioxoisoindolin-2-yl)propanoic acid is playing an increasingly important role. we look forward to future research findings about 3339-73-9.
Reference:
Article; Huang, Wenhua; Sha, Wen-Bin; Journal of Chemical Research; vol. 37; 8; (2013); p. 460 – 463;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem