Application of 317-20-4,Some common heterocyclic compound, 317-20-4, name is 7-Fluoroisatin, molecular formula is C8H4FNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
7-Fluoroisatin (1 mmol) was added to the microwave reaction tube,4-hydroxycoumarin (1.1 mmol),Tetrabutylammonium chloride (0.1 mmol) and water (4 mL),Microwave power 400W,60 radiation 15min,Stop microwave radiation,Cool to room temperature,Vacuum suction filtration,The filter cake was washed with ice-ethanol (0.5 ml)Drying under reduced pressure,A white solid,Yield 94%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Fluoroisatin, its application will become more common.
Reference:
Patent; Zunyi Medical College; Zhang Lei; Wang Jing; Liu Lai; Zheng Chengyue; Wang Yang; (4 pag.)CN107098888; (2017); A;,
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