Application of 1504-06-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1504-06-9 name is 3-Methyloxindole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3-methylindolin-2-one (441 mg, 3 mmol) in acetonitrile (5 mL) was cooled to 15C. NBS (534 mg,3 mmol) was added. After stirring for 1 h, the reaction was diluted with water (10 mL) and extractedwith EtOAc (20 mL) for three times. The combined organic phase was washed with brine, dried overNa2SO4 and concentrated under reduced pressure to give a residue which was purified by silica gelcolumn chromatography to afford compound 1b (454 mg, 67%) as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methyloxindole, and friends who are interested can also refer to it.
Reference:
Article; Zhao, Xia; Wei, Aoqi; Lu, Xiaoyu; Lu, Kui; Molecules; vol. 22; 8; (2017);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem