Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 129487-92-9, name is tert-Butyl 5-aminoindoline-1-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Safety of tert-Butyl 5-aminoindoline-1-carboxylate
To a solution of 300mg (1.28mmol) of the compound obtained in the Manufacturing Example 2 in 10mL of anhydrous dichloromethane were added 191muL (2.69mmol) of acetyl chloride and 375muL (2.69mmol) of triethylamine, and the mixture was stirred for 1 hour at room temperature. Then, water was added to the reaction mixture and the mixture was extracted with dichloromethane. The organic layer was dried over with anhydrous sodium sulfate and removed under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 1/1 to 1/2) to give 370mg (quantitative) of the title compound.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 129487-92-9.
Reference:
Patent; Daiichi Asubio Pharma Co., Ltd.; EP1775298; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem