Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5394-18-3, name is 2-(4-Bromobutyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Product Details of 5394-18-3
Preparation of l-Cyclohexyl-N-(4-(4-(6-nitropyridin-2-yl)piperazin-l- yl)butyl)methane-sulfonamide (Method A)N-(2-Bromobutyll)-phthalimide (2.82 g, 10 mmol) was dissolved in acetonitrile (6 mL) and 1-Boc-piperazine (1.82 g, 10 mmol) then diisopropylethylamine (1.87 mL, 10.74 mmol) were added at ambient temperature. The reaction mixture was split into two 10 mL microwave glass tubes then heated at 130 C for 15 min in the microwave oven.TLC (ethyl acetate/petrol 1: 1) showed a small amount of starting materials still present and a major product. The reaction mixture was evaporated to dryness and the yellow residue was dissolved in dichloromethane (20 mL) and washed with 10% aqueous potassium carbonate (30 mL), then the aqueous layer was washed twice with dichloromethane (10 mL). The organic layers were combined then evaporated to dryness to give a yellow oil which was purified by chromatography on silica gel (50 g) using 5-100% ethyl acetate in petrol gradient to at a flow of 40 mL/min to give the product as a white solid 3.1 g (80%).LCMS: calcd for C21H29N3O4 387.2; found 388.2 [M+H] .
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GE HEALTHCARE LIMITED; MEDI-PHYSICS, INC.; NEWINGTON, Ian, Martin; WYNN, Duncan George; NAIRNE, Robert James Domett; GUILBERT, Benedicte; MANDAL, Subrata; JINTO, Jose; VARADARAJAN, Sunderaraman; RANGASWAMY, Chitralekha; BETTS, Helen; DAVIS, Rebecca; WO2011/150183; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem