In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3335-98-6 as follows. Safety of 1-Phenyloxindole
A typical procedure: Tf2O (203 mg, 0.72 mmol) in CH2Cl2 (5 mL) were added at room temperature to a solution of azulene (1) (67 mg, 0.52 mmol) and 2-indolinone (101 mg, 0.76 mmol) in CH2Cl2 (15 mL). The resulting solution was stirred at the same temperature for 2.5 hours. The reaction mixture was poured into a 2 M K2CO3 solution, extracted with AcOEt, washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by column chromatography on silica gel with hexane/AcOEt (10:1) as an eluent to give 1-(indol-2-yl)azulene (2) (113 mg, 89%) as green crystals.
According to the analysis of related databases, 3335-98-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Shoji, Taku; Inoue, Yuta; Ito, Shunji; Tetrahedron Letters; vol. 53; 12; (2012); p. 1493 – 1496;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem