The important role of 32692-19-6

The synthetic route of 5-Nitroindoline has been constantly updated, and we look forward to future research findings.

Reference of 32692-19-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 32692-19-6, name is 5-Nitroindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A solution of 5-nitro-2,3-dihydro-lH-mdole (1.0 g, 6.1 mM) in DMF is treated with CsCO3 (3.0 g, 9.1 mM) and 2-Chloro-N,N-diethyl-acetamide (1.1 g, 7.3 mM) and heated to 8O0C for 16 hours. The solution Is cooled, poured into water, extracted with EtOAc, the organic layer separated, dried (MgSO4) and the solvent removed at reduced pressure. The residue is recrystallized from EtOH. This solid is suspended in EtOH, treated with 10% Pd/C (0.2 g) and the reaction hydrogenated on a Parr Shaker at 50 psi for 2 hours. The reaction is then filtered and the solvent removed at reduced pressure to give the product as a gray solid (0.8 g, 13%). LC/MS 0.46 min. 249 (M+H, 100%); IH-NMR (300 MHz, DMSO-d6) delta 6.56 (m, IH), 6.51 (m, IH), 6.45 (s, IH), 3.80 (bs, 2H)5 3.62 (s, 2H), 3.30 (m, 2H), 3.26 (m, 4H), 2.91 (m, 2H), 1.21 (s, 3H), 1.20 (s, 3H).

The synthetic route of 5-Nitroindoline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2007/97697; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem