Related Products of 1337533-31-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1337533-31-9, name is tert-Butyl 5-bromo-4-fluoroindoline-1-carboxylate belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of terr-butyl 5-bromo-4-fluoroindoline-l-carboxylate (2.0 g, 6.33 mmol), 1- methyl-4-(4,4,5,5-tetramethyl- 1,3 ,2-dioxaborolan-2-yl)- IH-pyrazole (2.0 g, 9.49 mmol) and Na2CO3 (2.0g. 18.98 mmol) in dioxane / 1-120 (27 mL, 3: 1) was added [1,V-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (461 mg, 0.63 mmol). The mixture room temperature, the mixture was concentrated in vacuo. The crude residue was purified bysilica gel chromatography (petroleum ether EtOAc 1: 1) to give the title compound (1.5 g, 75%) as a brown solid.
The synthetic route of tert-Butyl 5-bromo-4-fluoroindoline-1-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ROMERO, F. Anthony; MAGNUSON, Steven; PASTOR, Richard; TSUI, Vickie Hsiao-Wei; MURRAY, Jeremy; CRAWFORD, Terry; ALBRECHT, Brian, K.; COTE, Alexandre; TAYLOR, Alexander, M.; LAI, Kwong Wah; CHEN, Kevin, X.; BRONNER, Sarah; ADLER, Marc; EGEN, Jackson; LIAO, Jiangpeng; WANG, Fei; CYR, Patrick; ZHU, Bing-Yan; KAUDER, Steven; (0 pag.)WO2016/86200; (2016); A1;,
Indoline – Wikipedia,
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