Reference of 341988-36-1,Some common heterocyclic compound, 341988-36-1, name is Methyl indoline-6-carboxylate, molecular formula is C10H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 7 1-(2-Bromoethyl)-6-methoxycarbonylindoline To 1,2-dibromoethane (15.7 ml) were added 6-methoxycarbonylindoline (2.41 g) and triethylamine (7.8 ml), and the mixture was stirred at 90¡ã C. for 2 hr. Ethyl acetate (150 ml) was added to the reaction mixture, and the mixture was washed with saturated brine (300 ml) and dried over Na2SO4. Ethyl acetate was evaporated under reduced pressure. The obtained residue was purified by column chromatography to give the title compound (1.71 g). IR v(neat) cm-1; 1713, 1611, 1499.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl indoline-6-carboxylate, its application will become more common.
Reference:
Patent; Matsui, Hiroshi; Kobayashi, Hideo; Azukizawa, Satoru; Kasai, Masayasu; Yoshimi, Akihisa; Shirahase, Hiroaki; US2003/27836; (2003); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem