Electric Literature of 112656-95-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112656-95-8, name is 7-Nitroindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Add 7-nitroisatin 3 (10g, 0.052mol) and tetrahydrofuran (200mL) to a 250mL reaction flask, add sodium borohydride (2.4g, 0.061mol) in portions, and add tetrachloride in portions under cooling in an ice bath. Zirconium (42.4 g, 0.182 mol).The temperature was raised to room temperature for 18 hours, and the starting material disappeared by HPLC.1 mol / L hydrochloric acid (50 mL) was slowly added dropwise to the reaction flask, stirred for 30 minutes, ethyl acetate (100 mL) was added, 100 mL of water was added, insoluble matter was filtered off, the filtrate was left to separate and the organic layer was washed with 100 mL of water, and concentrated A yellow crude product was obtained, which was recrystallized from ethyl acetate and n-heptane to obtain 7.2 g of yellow crystals with a yield of 86% and a purity of 98.2%.
The synthetic route of 7-Nitroindoline-2,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangsu Suli Fine Chemical Co., Ltd.; Wang Jingli; Yang Kai; Fei Zhongbo; Cao Wenli; Wang Liyang; Ding Shaocong; (6 pag.)CN110845388; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem