Reference of 181140-34-1, These common heterocyclic compound, 181140-34-1, name is (R)-(-)-N-(2,3-Epoxypropyl)phthalimide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 243.9 g (1.20 mol) of S – (+) – N- (2,3-ethoxypropyl) phthalimide (SM1), 121.8 g (800.30 mmol)2- (4-aminophenylamino) ethanol was added to 3L three-necked flask in turn, then 2.0L of anhydrous ethanol was added, and the temperature was raised at 75-85C for 24 h. With tap water to 40 ~ 45 , filter, washed with ethanol, filter cake, white solid. And dried at 50 to 60 C under reduced pressure for 5 hours. To give 256.0 g of compound I in a yield of 90.0%.
Statistics shows that (R)-(-)-N-(2,3-Epoxypropyl)phthalimide is playing an increasingly important role. we look forward to future research findings about 181140-34-1.
Reference:
Patent; Chongqing Zhien Pharmaceutical Co., Ltd.; Deng Xianglin; Li Daming; Huang Chaoming; Huang Minghui; Feng Yongmei; Wang Fei; Liao Xingting; (29 pag.)CN106432218; (2017); A;,
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