Reference of 7147-90-2, A common heterocyclic compound, 7147-90-2, name is 5-Chloroisoindoline-1,3-dione, molecular formula is C8H4ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The intermediate compound 4 (0.05 mol) was slowly added to 30 ml of 0 C concentrated H2SO4,Control the temperature does not exceed 12 C; added, ice bath conditions slowly add mixed acid (fuming nitric acid / concentrated sulfuric acid = 1/1) 15ml, remove the ice bath, 55 C heating and stirring for 12 hours. The reaction solution was poured into 3 times of ice water, and the mixture was stirred while stirring, and the solid was filtered. The filter cake was washed three times with 100 ml of water and recrystallized from 95% ethanol to give intermediate 11 as a pale yellow solid in 16%
The synthetic route of 7147-90-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong University; Zhao Guisen; Liu Yang; Geng Jingkun; Li Yijing; (15 pag.)CN104447496; (2017); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem