In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 261732-38-1 as follows. Application In Synthesis of tert-Butyl 5-bromoindoline-1-carboxylate
A solution of the title B compound, 5-bromo-2, 3-DIHYDRO-INDOLE-1-CARBOXYLIC acid tert-butyl ester (15.86 g, 53.22 mmol) in 500 mL THF is cooled TO-73C and treated with n-butyllithium (1.6 M in hexanes, 53.22 mL, 85.15 MMOL). After 15 min AT-73C, dry COs is bubbled through the solution for 40 min. The reaction is kept AT-73C for 1 h, warmed to 0C for 1 h, and then warmed to RT for 1 h. The mixture is poured into 1 N aqueous HCI and extracted twice with diethyl ether. The diethyl ether layers are combined, washed with brine, dried over anhydrous MGS04, and concentrated to afford of 2, 3-dihydro-indole-1, 5-dicarboxylic acid 1-tert-butyl ester as an white solid : NMR (DMSO-D6) 1.51 (s, 9H), 3.10 (t, 2H, J = 8.75), 3. 69 (t, 2H, J = 8.80), 7.73-7. 79 (m, 3 H), 12.62 (br s, 1 H).
According to the analysis of related databases, 261732-38-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/65351; (2004); A1;,
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