Adding a certain compound to certain chemical reactions, such as: 16800-68-3, name is 1-Acetylindolin-3-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16800-68-3, Recommanded Product: 16800-68-3
General procedure: 1a (35 mg, 0.2 mmol, 1 equiv.), tert-BuOK (22.4 mg, 0.2 mmol, 1.0 equiv.) were added to a Schlenk tube. Then 2 mL THF was added using a syringe. The reaction mixture was stirred 15 min,and then 6 ( 0.2 mmol, 1.0 eq) was added, and the reaction was stirred at room temperature for 10 hours. the solvent was removed in vacuo and the residue was purified by silica gel using a propereluent (EtOAc/Hexane) to afford the desired products.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Acetylindolin-3-one, and friends who are interested can also refer to it.
Reference:
Article; Zhang, Yanxia; Han, Jianwei; Liu, Zhen-Jiang; Synlett; vol. 26; 18; (2015); p. 2593 – 2597;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem