Synthetic Route of 6941-75-9, These common heterocyclic compound, 6941-75-9, name is 5-Bromoisoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirring room temperature solution of 4-bromophthalimide (1.02 g, 4.51 mmol) in dimethylformamide (20 mL) add 60% sodium hydride (0.235 g, 5.87 mmol). Stir this mixture at ambient temperature for 15 minutes and then add iodomethane (0.628 mL, 10.09 mmol). Stir the reaction for 30 minutes at ambient temperature then quench it with brine. Extract the resulting aqueous mixture with ethyl acetate. Wash the combined extracts with brine; dry (sodium sulfate) and concentrate them in vacuo. Purify the resulting material on a flash column (silica gel; 70%-100% CH2C12 gradient in hexanes) to obtain the title compound, 0.960 g (89%). MS (IS+) 7nle 240 (M + H’79Br), 242 (M + H, “Br).
The synthetic route of 6941-75-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/73205; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem