Reference of 825-70-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 825-70-7 as follows.
Step 2a:(R)-1-(5-Fluoro-2-methyl-2,3-dihydroindol-1-yl)-2-phenoxypropan-1-one: diastereoisomer A And(R)-1-(5-Fluoro-2-methyl-2,3-dihydroindol-1-yl)-2-phenoxypropan-1-one: diastereoisomer B 2.9 g of 5-Fluoro-2-methyl-2,3-dihydro-1H-indole and 5.3 g of N-[3-(dimethylamino)propyl]-N?-ethylcarbodiimide hydrochloride are added to a solution of 4.17 g of o-benzyl-D-lactic acid in 17 ml of DMF and 3.43 ml of pyridine.The reaction medium is stirred at ambient temperature for 18 hours.500 ml of ethyl acetate and 500 ml of water are added. After settling out, the organic phase is dried over magnesium sulfate, filtered, and then concentrated under reduced pressure. The residue obtained is purified on a silica cartridge: eluent: heptane, then 95/05 heptane/ethyl acetate, then 90/10 heptane/ethyl acetate, so as to give 2.8 g of (R)-1-(5-fluoro-2-methyl-2,3-dihydroindol-1-yl)-2-phenoxypropan-1-one: diastereoisomer A in the form of a yellow oil, the characteristics of which are the following:Mass spectrometry: method ARetention time Tr (min)=1.08;[M+H]+: m/z 314And 2.63 g of (R)-1-(5-fluoro-2-methyl-2,3-dihydroindol-1-yl)-2-phenoxpropan-1-one: diastereoisomer B in the form of a white solid, the characteristics of which are the following:Mass spectrometry: method ARetention time Tr (min)=1.06;[M+H]+: m/z 314; base peak: m/z 242
According to the analysis of related databases, 825-70-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANOFI; Brollo, Maurice; Carry, Jean-Christophe; Certal, Victor; Didier, Eric; Doerflinger, Gilles; EL Ahmad, Youssef; Filoche-Romme, Bruno; Halley, Frank; Karlsson, Karl Andreas; Schio, Laurent; Thompson, Fabienne; US2013/274253; (2013); A1;,
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