1127-59-9, name is 7-Methylindoline-2,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 1127-59-9
Preparation of 7-bromomethylisatin The 7-methylisatin (16.1 g, 0.1 mole) is suspended in dichloroethane (2000 ml) and the suspension is heated and irradiated with a high intensity light source to the reflux point. Bromine (24.3 g, 0.15 mole) is added dropwise over a one hour period. The solution is filtered hot and concentrated at reduced pressure to yield the product as an orange solid after washing with anhydrous diethyl ether. The product is purified using flash chromatography on silica (elution with 24:1 dichloromethane:diethyl ether) to afford after drying (at 60¡ã C. at 0.1 mm); 7-bromomethylisatin, mp 199¡ã-200¡ã C. dec.
The synthetic route of 1127-59-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Warner-Lambert Company; US4582909; (1986); A;,
Indoline – Wikipedia,
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