496-12-8, name is Isoindoline, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: indolines-derivatives
General procedure: A mixture of the amine (2.0 mmol), EDC (2.6 mmol), and HOBt (3.3 mmol) were purged with nitrogen before the addition of the acid (2.6 mmol) and THF (10 ml). DIPEA (11.0 mmol) was then added and the reaction was stirred at room temperature for 16 h. The reaction mixture was poured into a separatory funnel containing saturated NH4Cl (10 ml) and extracted with ethyl acetate (3 ¡Á 30 ml). The combined organic layers were dried over Na2SO4, concentrated under vacuum. Purification on silica gel yielded the desired product.
The synthetic route of 496-12-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Awuah, Emelia; Ma, Eric; Hoegl, Annabelle; Vong, Kenward; Habib, Eric; Auclair, Karine; Bioorganic and Medicinal Chemistry; vol. 22; 12; (2014); p. 3083 – 3090;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem