Adding a certain compound to certain chemical reactions, such as: 126674-93-9, name is 4,6-Difluoro-1H-indole-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 126674-93-9, Formula: C8H3F2NO2
[Reference Example 154] (0739) (0740) To the solution of 250 mg of 4,6-difluoro-1H-indole-2,3-dione in 3 mL of sulfuric acid, 109 muL of 60% nitric acid was added dropwise at -20C, and the resultant was stirred for 15 minutes. Water was added dropwise to the reaction mixture, followed by addition of ethyl acetate. The organic layer was separated, sequentially washed with a saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (gradient elution with hexane:ethyl acetate) to give 180 mg of 4,6-difluoro-5-nitro-1H-indole-2,3-dione as a yellow solid. 1H-NMR (DMSO-d6) delta: 6.95 (1H, d, J = 10.6 Hz), 11.95 (1H, s) MS (ESI, m/z): 227 (M-H)-.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,6-Difluoro-1H-indole-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Toyama Chemical Co., Ltd.; FUJIFILM Corporation; TANAKA, Tadashi; KONISHI, Yoshitake; KUBO, Daisuke; FUJINO, Masataka; DOI, Issei; NAKAGAWA, Daisuke; MURAKAMI, Tatsuya; YAMAKAWA, Takayuki; EP2915804; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem