Application of 52537-00-5

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52537-00-5, name is 6-Chloro-2,3-dihydro-1H-indole belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole

A mixture of tert-butyl 2-(4-amino-2-(4-bromo-l-methyl-lH-pyrazol-5-yl)rhohenoxy) ethylcarbamate (30 mg, 54 mumol) and 6-chloroindoline (8.3 mg, 54 mumol) in ImL of DMF was stirred at room temperature overnight. Then to the mixture was added 1 mL of 2M HCl. The mixture was stirred at room temperature overnight. The mixture was concentrated and the crude product was subjected to purification on HPLC. The proper fractions were collected and lyophilized to afford yellow oil in 20.1 % yield. LCMS m/z (%) = 492 (M+H 35Cl 79Br, 100). 1H NMR (400 MHz, MeOD) delta ppm 3.1 (m, 4 H), 3.7 (s, 3 H)3 4.1 (m, 3 H), 4.2 (m, 1 H), 6.8 (dd, J=7.6, 2.0 Hz, 1 H), 7.1 (d, 3=7.6 Hz, 1 H), 7.1 (d, J=9.1 Hz, 1 H), 7.3 (d, J=3.0 Hz, 1 H), 7.5 (s, 1 H), 7.6 (dd, J=9.1, 2.5 Hz, 1 H)5 7.8 (d, J=2.0 Hz, 1 H).

The synthetic route of 52537-00-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2007/136703; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem