Electric Literature of 6872-06-6,Some common heterocyclic compound, 6872-06-6, name is 2-Methylindoline, molecular formula is C9H11N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Pd(OAc)2 (1.12 mg, 0.005 mmol), Zn(OTf)2 (3.63 mg, 0.01 mmol) were dissolved in 5 mL acetonitrile in a glass tube, after stirring for 10 min, indoline (60 mg, 0.5 mmol) were added. The glass tube was equipped with a reflux condenser. Next, the reaction solution was magnetically stirred at 353K in oil bath for 6 h with O2 balloon. The product analysis was performed by GC using the internal standard method. Control experiments including using Pd(OAc)2, or Zn(OTf)2 alone were carried out in parallel.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methylindoline, its application will become more common.
Reference:
Article; Lou, Chenlin; Qin, Shuhao; Zhang, Sicheng; Lv, Zhanao; Senan, Ahmed M.; Chen, Zhuqi; Yin, Guochuan; Catalysis Communications; vol. 90; (2017); p. 5 – 9;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem