Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 959235-95-1, name is 6-(Trifluoromethoxy)indoline, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C9H8F3NO
A mixture of 6-(trifluoromethoxy)indoline [CAS 959235-95-1] (2 g, 9.84 mmol), 2- (4-fluoro-2-methoxyphenyl)acetic acid [CAS 886498-61 -9] (2.17 g, 10.8 mmol), HATU (5.62 g, 14.8 mmol) and diisopropylethylamine (4.9 mL, 29.5 mmol) in DMF (20 mL) was stirred at room temperature for 3 h. Water and ice were added and the precipitate was filtered off and dried to give 2-(4-fluoro-2-methoxyphenyl)-1 -(6- (trifluoromethoxy)indolin-1 -yl)ethanone 6a (3.44 g).
According to the analysis of related databases, 959235-95-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICALS, INC.; KATHOLIEKE UNIVERSITEIT LEUVEN; BONFANTI, Jean-Francois; KESTELEYN, Bart, Rudolf, Romanie; BARDIOT, Dorothee, Alice, Marie-Eve; MARCHAND, Arnaud, Didier, M; COESEMANS, Erwin; DE BOECK, Benoit, Christian, Albert, Ghislain; RABOISSON, Pierre, Jean-Marie, Bernard; (79 pag.)WO2018/215316; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem