Application of 317-20-4, These common heterocyclic compound, 317-20-4, name is 7-Fluoroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Is added to the reactor 132 mg (0.8 mmol) 7 – fluoro – isatin and 215.1 mg (0.96 mmol) 1, 3 – diphenyl – 1, 3 – c diketone, add 50 ml toluene and 5 ml DMF as the reaction solvent, adding 1 ml H2O2And the catalytic amount of the strong acid ion resin D001 as catalyst, electric jacket heated to 110 C, magnetic stirring reflux reaction for 8.5 hours. Thin-layer chromatographic trace to after the reaction is complete, evaporating the solvent under reduced pressure,, the resulting mixture by silica gel column chromatography separation and purification, drying to obtain the target compound 190.6 mg, total yield 64.2%.
Statistics shows that 7-Fluoroisatin is playing an increasingly important role. we look forward to future research findings about 317-20-4.
Reference:
Patent; Shaanxi University of Science and Technology; Liang Chengyuan; Tian Danni; Jia Minyi; Wang Xuechuan; Dong Hao; Wang Qiang; (12 pag.)CN108558895; (2018); A;,
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