These common heterocyclic compound, 20870-79-5, name is 5-Nitroindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5-Nitroindolin-2-one
General procedure: Aldehyde (1 mmol) and active methylene component (2.5 mmol) were dissolved in dimethylformamide in a microwave vial, piperidine was added in catalytic amount andthen the reaction mixture was subjected to microwave irradiations for 1h at 150 C. A solid product was separated out which was then filtered andwashed with cold water. The products were further purified by washing with ether/ethanol.
The synthetic route of 5-Nitroindolin-2-one has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kaur, Jagroop; Kaur, Sukhmeet; Singh, Palwinder; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 1936 – 1940;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem